Dace GARDOVSKA

Professor, Dr.habil.med.  Dace Gardovska Head of the Department of Paediatrics, Riga Stradins University Head, Clinic of Paediatrics, Children University Hospital. Dzirciema iela 16 Riga, LV 1007 Latvia Phone: +371 67621730 Fax: +371 67621730 E-mail: [email protected]

Born: December 30, 1952

• main field: paediatrics, paediatric infectious diseases
• other fields: immmunology,medical education

Current research interests: severe infections in children, SIRS, sepsis.

Languages: Latvian, Russian , English

• Riga Medical Institute, Faculty of paediatrics, physician – paediatrician, 1977
• Riga Medical Institute, postgraduate clinical studies in pediatric intensive care, 1979
• Institute of Evolutionary Physiology and Biochemistry of I. Sechenov, Leningrad, postgraduate doctoral studies,1982

• Dr med. (thesis „Reactivity of brain circulation in children”), 1983
• Dr. habil. med.(thesis „Immunodeficiency in children in Latvia”), 1996

• Head/professor, Department of Paediatrics, Riga Stradins University ; Head, Clinic of Paediatrics, Children University Hospital, 1998 – present
• Dean, Faculty of Postgraduate Education, Riga Stradins University, 1997 – 2004
• Head, Department of Pediatric Infectious Diseases, Medical Academy of Latvia; Head, Clinic of Pediatric Infectious Diseases, Children University Hospital, 1992 – 1998
• Associate professor, Pediatric Department, Riga Medical Institute, 1986 –1992
• Assistant professor, Pediatric Department, Riga Medical Institute, 1979 – 1986

- paediatrics
- paaediatric infectious diseases

• Cross of Recognition ( the Officer of the Cross of Recognition) 2007
• Corresponding Member, Latvian Academy of Sciences, 2009

• Member of the Chapter of Orders
• President, Society for Specialized Paediatrics of Latvia.
• President, Society for Paediatric Infectious Diseases of Latvia.
• Member of Promotion Board (Internal Medicine), Riga Stradins University
• Member of the National Committee for Poliomyelitis Eradication,
• Member of the State Immunization Committee
• Physician Society of Latvia, Member of the Board
• Member of ESPID 

Recent/Representative Publications 

• Pavare J, Grope I, Gardovska D. Prevalence of systemic inflammatory response syndrome (SIRS) in hospitalized children: a point prevalence study. - BMC Pediatr., 2009 Apr 3;9:25. PubMed PMID: 19344519; PubMed Central PMCID: PMC2670291.
• J.Pavare, I. Grope, L.Eihvalde, D. Gardovska. Diagnostic markers for sepsis identification in patients with systemic inflammatory response syndrome (SIRS): a prospective study. -  The Open Pediatric Medicine Journal, 2009, vol. 3, pp.1-7 (Bentham Science Publishers).
• E. Kviesis-Kipge, E. Curkste, J. Spigulis and D. Gardovska. Optical Studies of the Capillary Refill Kinetics in Fingertips. - In: O. Dossel and W.C. Schlegel (Eds.): WC 2009, IFMBE Proceedings 25/VII, 2009, pp. 377–379. www.springerlink.com
• Jana Pavare, Ilze Grope, Imants Kalnins, and Dace Gardovska. Diagnostic markers for early sepsis diagnosis in children with systemic inflammatory response syndrome. -  Proc. Latv. Acad. Sci.,   . Section B, 2009, Vol. 63, No. 4/5 (663/664), pp. 20–30.
• Rimoin AW, Walker CL, Chitale RA, Hamza HS, Vince A, Gardovska D, da Cunha AL, Qazi S, Steinhoff MC. Variation in clinical presentation of childhood group A streptococcal pharyngitis in four countries. - J Trop Pediatr., 2008 Oct, vol. 54(5), pp.308-312. Epub 2008 Mar 29. PMID: 18375971 [PubMed - indexed for MEDLINE].
• Simanis R, Lejniece S, Sochnevs A, Eglite J, Chernevska G, Kovalova Z, Gardovska D, Jeruma A, Kuse V, Viksna L. Natural clearance of hepatitis C virus in hemophilia patients.- Medicina (Kaunas). 2008, vol. 44(1), pp.15-21. PMID: 18277084 [PubMed - indexed for MEDLINE].
• V. Stanevicha, D. Zavadska, I. Eglite, A. Sochnevs, R. Shantere, D. Gardovska. HLA class II DR and DQ genotypes and haplotypes associated with homogeneous rheumatic heart disease in children in Latvia. - Collection of Scientific Papers 2007, publicated in 2008; pp. 6-14.
• D.Zavadska, L.Drukalska, N. Pugacova, D. Berziņa, D.Gardovska, V. Stanevicha, E.Miklashevich. Antimicrobal therapy resistance in group A beta haemolytic Streptococcus infection and rheumatic fever. - Joint Bone Spine,  2008, Vol. 75, N2, pp. 244-245.
• Stanevicha V, Eglite J, Zavadska D, Sochnevs A, Shantere R, Gardovska D. HLA class II DR and DQ genotypes and haplotypes associated with rheumatic fever among a clinically homogeneous patient population of Latvian children. - Arthritis Res Ther.,  2007, vol. 9(3), R58. PubMed PMID: 17559688; PubMed Central PMCID: PMC2206337.
• D. Zavadska, V. Stanevicha, I. Eglite, A. Sochnevs, D. Gardovska, R. Shantere. HLA Class II DR and DQ genotyps and haplotyps associated with rheumatic heart disease among clinically homogeneous patients in children in Latvia. - Joint Bone Spine, Revue du rheumatisme international edition; 2007. 03.,  vol. 74, pp 218.
• D.Gardovska, J.Livdane, I.Grope. Curriculum of postgraduate education in paediatrics in Latvia.- GMS Zeitschrift für Medizinische Ausbildung ISSN 1860-3572, 2007, vol. 24(4), Doc 177.
• D.Gardovska, J.Livdane.”Europeanization” of Latvian Paediatric curriculum. - GMS Zeitschrift für Medizinische Ausbildung ISSN 1860-3572, 2007, vol. 24(4), Doc 182.
• D. Gardovska, J. Pavare, I. Grope, A. Petersons, D. Pugachevska. A point prevalence survey of systemic inflammatory response syndrome (SIRS) in different pediatric patients of Children’s clinical university hospital in Latvia. -  Acta Chirurgica Latviensis, 2007, N7, pp. 28-32.
• D. Gardovska, A. Petersons, J. Gardovskis Immune response to acute and reccurent, chronic respiratory diseases in young children.. - XXXV World Congress of International College of Surgeons, Pattaya (Thailand), October 25-29, 2006, Medimond International Proceedings, pp. 209-212.
• Cizman M, Beovic B, Krcmery V, Barsic B, Tamm E, Ludwig E, Pelemis M, KarovskiK, Grzesiowski P, Gardovska D, Volokha A, Keuleyan E, Stratchounski L, Dumitru C,Titov LP, Usonis V, Dvorak P. Antimicrobial Susceptibility Patterns of Enterococci Causing Infections in Europe. - Antimicrob Agents Chemother. 1999 October; vol. 43(10), pp. 2542–2546.  Antibiotic policies in Central Eastern Europe. - Int J Antimicrob Agents,  2004 Sep; vol. 24(3), pp. 199-204. PubMed PMID: 15325421.
• U. Dumpis, Z. Kovalova, J. Jansons, L.Cupane, I. Sominskaya, M. Michailova, P. Karaviannis, D. Gardovska, S.Viazov, S. Ross, M. Roggendorf, and P. Pumpens. An Outbreak of HBV and HCV Infection in a Paediatric Oncology Ward: Epidemiological investigation and prevention of Further Spread. -  Journal of Medical Virology,  2003, vol. 69, pp. 331-338, PubMed PMID: 12526042.
• V.Stanevicha, J.Eglite, A.Sochnevs, D.Gardovska, D. Zavadska, R.Shantere. HLA Class II Associations with Rheumatic Heart Disease among Clinically Homogeneous Patients in children in Latvia. - Arthritis Res Ther., 2003, vol. 5(6), R 340-6. Epub 2003 Sep 8. PubMed PMID: 14680508; PubMed Central PMCID: PMC333411.
• Grope I., Gardovska D. Acute nontyphoidal salmonellosis today. -  Proc. Latv. Acad. Sci. Sect.B., 2001, vol. 55, N 1, pp.1-5.
• Grope I, Gardovska D.  A comparative analysis of the properties of bacteria in the genus Salmonella isolated from children in Latvia . - Antibiot Khimioter., 2000,  vol. 45(1), pp. 21-24. Russian. PubMed PMID: 10690424.
• Bradford PA, Yang Y, Sahm D, Grope I, Gardovska D, Storch G. CTX-M-5, a novel cefotaxime-hydrolyzing beta-lactamase from an outbreak of Salmonella typhimurium in Latvia. - Antimicrob. Agents Chemother.,  1998 Aug; vol. 42(8), pp. 1980-1984. PubMed PMID:9687393; PubMed Central PMCID: PMC105719N.
• N. Osna, G. Silonova, M. Ponomareva, D. Gardovska, L. Viksna, A. Socnevs. Interferon alfa low dosage course induces biochemical response and immunomodulation in chronic hepatitis B. -  Central  European J. of Immunology - 1998, Vol.23, N 1,   pp.62-68.
• D. Gardovska, N. Osna, M. Ponomarjova, A. Sochnev, V. Andrejev, M. Makricas. Core – antigen reactive lymphocytes in chronic hepatitis C . -  Hepatology, 1996, vol.26, pp.25 – 26.
• D. Gardovska, A. Sochnev. The immune system in young children with acute, recurrent and chronic respiratory diseases. -  Latvijas Zinatņu Akademijas Vestis, 1995, Nr. 11/12, pp. 134-137.
• D. Gardovska, L. Samoshenkova. The functional activity of lymphocytes in children with chronic localized bronchitis. - Latvijas Zinatnu Akademijas Vestis, 1995, Nr. 11/12, pp. 138-141.
• Livshits , Gardovska DKh , Grinberg VIa , Eksta IIa , Platkaia EK . Clinico - immunological aspects of gastrointestinal diseases in children. - Pediatriia , 1991, vol. 9, pp. 11-17. Russian. PubMed PMID: 1754340.
• Moskalenko IuE, Krivchenko AI, Pavlov NA, Gardovska DKh. Comparative physiological aspects of the functional resistance of cerebral circulation.- Zh Evol Biokhim Fiziol., 1983 Jul-Aug, vol. 19(4), pp. 374-80. Russian. PubMed PMID: 6415966.
• Moskalenko J, Khilko V, Vainshtein G, Gardovska DH, Semernia VN. Inform ativeness of indices of reactions of cerebral vessels to adequatetimuli. - Fiziol Zh SSSR Im I M Sechenova, 1982 Feb, vol. 68(2), pp. 284-292. Russian. PubMedPMID: 7075832.

Research projects ( principal investigator ) :

National Research Programme in Medicine. Multi-disciplinary research consortium on major pathologies threatening the life expectancy and quality of life of the Latvian population.

WHO project. Development of a clinical prediction instrument for group a beta hemolytic streptococcal  pharyngitis in children.

• Clinical, biochemical and molecularly-genetical characterization of diseases caused by particular microorganisms, influencing substantially the quality of life in Latvia - Borrelia burgdorferi sensu lato complex bacteria, RSV and hMPV; personalized approach for diagnostics and cure, forecasting of disease progression
• Significant lower respiratory tract infections caused by Pneumoviruses in children, their clinical and molecular description in tertiary level children’s hospital in Latvia.
• Predictive factors for group A beta hemolytic streptococcal pharyngitis, rheumatic fever and rheumatic heart disease in children in Latvia
• IgA deficiency – epidemiology, immunogenetics and role in immunopathogenesis of chronic and recurrent diseases in children in Latvia”
• Hematological malignancies in children with combined chronic viral infection
• Disturbances of cytokine system in chronic hepatitis C in children
• Immunoregulation in children with persistent intracellular infections – chronic hepatitis B and C.

Ministry of Education and Science of Latvia (grant ). Sepsis – diagnosis, differential diagnosis, monitoring and treatment.

Last update 08.02.2010