Lubov IGNATOVICH

Dr.habil.chem. Lubov IGNATOVICH Principal scientist Head of the Laboratory of Organometallic Chemistry Latvian Institute of Organic Synthesis 21, Aizkraukles str., Riga, LV-1006, Latvia Phone: +371 7553355; +371 29590575 e-mail: [email protected]; [email protected]

Born: 1953 July 8,   Rezekne, Latvia

Interests:

• Organometallic (silicon, germanium, tin) chemistry
• Penta- and hexa-coordinated organosilicon and germanium compounds
• Chemistry of heterocycles (furan, thiophene, pyrimidine)
• Synthesis of biologically active compounds
  

Languages: Russian, Latvian, English

Education:

• University of Latvia (Faculty of Chemistry), 1976
• Dr.chem. (Candidate of Science in former USSR, Ph.D. in Western countries), Institute of Organic Synthesis, Riga, 1985  
                     Thesis: "Synthesis and transformations of furylgermanes”
• Dr.habil.chem., University of Latvia, Riga,   1998
                      Thesis: “Synthesis, structure and biological activity of germyl- and germaheterocycles”

Experience:    Latvian Institute of Organic Synthesis –

• Scientific coworker, 1971-1976
• Engineer, 1976 -1981
• Junior Researcher, 1982-1985Researcher,  1985-1989
• Senior Researcher (Principal scientist),  1989 - 2009
• Head of the Laboratory of Organometallic Chemistry

  Visiting researcher:

• ICIDCA, Habana, Cuba (Dr. Irma Castro-Mendez), 1988
• Cuban University, Habana, Cuba (Prof. Margarita Suaresh), 1989
• Tsukuba University, Tsukuba, Japan (Prof. Wataru Ando), 1990
• Tohoku University, Sendai, Japan (Prof. Hideki Sakurai), 1991
• Tohoku University, Sendai, Japan (Prof. Hideki Sakurai), 1992
• RIKEN, Sendai, Japan (Prof. Mitsuo Kira), 1993 -1994
• Taiho Pharmaceutical Co., Ltd., Japan (Dr. Tetsuo Asao), 1997
• Taiho Pharmaceutical Co., Ltd., Japan (Dr. Tetsuo Asao), 2001

Awards:

• The Latvian Academy of Sciences Presidium Award 1992
• Person of the Year Award (Marqui's Who's Who in the World), 2009
• Margus's Who's Who in Science and Engineering 2008 - 2009.

Plenary and invited Lectures:

• IV All-Union Conference on the Chemistry of Nitrogen-contaning Heterocyclic Compounds (Novosibirsk, USSR), 1987
• XVII All-Union Conference on the Synthesis and Reactivity of Organic Compounds of Sulfur (Tbilisi, USSR), 1989
• Tohoku University (Sendai, Japan), 1992
• University of Toulouse (France), 1994
• International Conference on environmental and biological aspects of main-group organometals (ICEBAMO 94), Bordeaux (France), 1994
• 5th Blue Danube symposium on heterocyclic chemistry (5th BDSHC), Chasta-Papernicka (Slovak Republic), 1995
• Nippon Soda Company, Odawara (Japan), 1997
• 5th International Conference on environmental and biological aspects of main-group organometals, Schielleiten (Austria), 2001
• Uppsala University (Uppsala, Sweden), 2004
• 14th International Symposium on Organosilicon Chemistry, Wurzburg, (Germany), 2005

1. Lukevics E., Gar T.K., Ignatovich L.M., Mironov V.F. Biological activity of germanium compounds.- Riga: Zinatne,1990.-191p. (in Russian).
2. Lukevics E., Ignatovich L. Uracil derivatives of Group 14 elements // Frontiers of organogermanium, -tin and -lead chemistry / Ed. By E. Lukevics, L.Ignatovich. – Riga: IOS,1993, 331-341.
3. Lukevics E., Ignatovich L. Toxicity of organogermanium compounds. The chemistry of organic germanium, tin and lead compounds / ed. By S. Patai. – Chichester: John Wiley & Sons, 1995, 857-863.
4. Belyakov S., Ignatovich L., Lukevics E. Concerning the transannular bond in silatranes and germatranes: a quantum chemical study // J. Organomet. Chem. , 1999, 577, 205-210.
5. Lukevics E., Ignatovich L., Belyakov S. Synthesis and molecular structure of phenyl and tolylgermatranes // J. Organomet. Chem., 1999, 588, 222-230.
6. Kira M., Ishida S., Ichinohe M., Kabuto C., Ignatovich L., Sakurai H. Synthesis and structure of a stable cyclic dialkylgermylene // Chem. Letters ,1999, 263-264.
7. Hashimoto H., Yagihashi Y., Ignatovich L., Kira M. Characterization and properties of 1,2-Disiladigerma-cyclobutane // Heteroatom Chem., 2001, 12,.398-405.
8. Ignatovich L., Zarina Dz., Shestakova I., Germane S., Lukevics E. Synthesis and biological activity of silyl- and germylsubstituted trifluoroacetylfurans // Metal-Based Drugs, 2002, 8, 211-214.
9. Lukevics E., Ignatovich L. Biological activity of organogermanium compounds. The Chemistry of Organic Germanium, Tin and Lead Compounds. Ed. Z.Rappoport, Chichester: John Wiley & Sons Ltd. 2002, 1651-1683.
10. Lukevics E., Ignatovich L, Shul’ga T., Belyakov S. Synthesis, molecular structure and biological activity of bromobenzylgermatranes // J. Organomet. Chem., 2002, 659, 165-171.
11. Lukevics E., Ignatovich L., Shestakova I.Synthesis, psychotropic and anticancer activity of 2,2-dimethyl-5-[5’-trialkylgermyl-(silyl)-2’-hetarylidene]-1,3-dioxane-4,6-diones and their analogues //Appl. Organomet. Chem., 2003, 17, 898-905.
12. Lukevics E., Ignatovich L. Biological Activity of Organosilicon Compounds. Metallotherapeutic Drugs and Metal-Based Diagnostic Agents. The Use of Metals in Medicine. Ed. M.Gielen, E.R.T.Tiekink. J.Wiley & Sons, Ltd., 2005(5), 83-107.
13. Lukevics E., Ignatovich L. Biological Activity of Organogermanium Compounds. Metallotherapeutic Drugs and Metal-Based Diagnostic Agents. The Use of Metals in Medicine. Ed. M.Gielen, E.R.T.Tiekink. J.Wiley & Sons, Ltd., 2005(15), 279-295.
14. Ignatovich L., Zarina D., Shestakova I., Germane S., Lukevics E. Synthesis and biological activity of silicon derivatives of 2-trifluoroacetylfuran and their oximes. Organosilicon Chemistry VI: Ed. by N.Auner and J.Weis. Wiley-VCH Verlag GmbH&Co.KGaA. 2005, From Molecules to Materials. Vol.1, Chapter 1, 563-568.
15. Lukevics E., Ignatovich L., Sleiksha I., Shestakova I., Domrachova I., Popelis J. Synthesis and cytotoxic activity of silacycloalkylsubstituted heterocyclic aldehydes and their thiosemicarbazones. //Appl. Organomet. Chem., 2005, 19, 1109-1113.
16. Ignatovich L., Popelis J., Lukevics E. Synthesis and NMR spectra of dyaryl- and dihetarylsilacycloalkanes. Organosilicon Chemistry VI: [Ed. by N.Auner and J.Weis. Wiley-VCH Verlag GmbH&Co.KGaA]. 2005, From Molecules to Materials. Vol.1, Chapter 1, 559-562.
17. Lukevics E., Ignatovich L., Sleiksha I., Muravenko V., Shestakova I., Belyakov S., Popelis J. Synthesis, structure and cytotoxic activity of 2-acetyl-5-trimethylsilylthiophene(furan) and their oximes. //Appl. Organomet. Chem., 2006, 20, 454-458.
18. Ignatovich L., Muravenko V., Grinberga S., Lukevics E. Novel reactions to form an Si-O-Ge group. // Chem. Heterocycl. Comp. , (Engl. Ed.). 2006, 42, 268-271.
19. Lukevics E., Ignatovich L., Sleiksha I., Romanov V., Grinberga S., Popelis J., Shestakova I. New synthetic way to silicon and germanium containing 2-acetylfurans and –thiophenes. // Chem.Heterocycl. Comp. (Engl. Ed.)., 2007, 43, 145-150.
20. Lukevics E., Ignatovich L., Belyakov S. Disordering in crystal structures of thienylgermatranes.// Chem. Heterocycl. Comp. (Engl. Ed.). 2007, 43, 243-249.
21. Soualami S., Ignatovich L., Lukevics E., Ourari A., Jouikov V. Electrochemical oxidation of benzylgermatranes.// J. Organomet. Chem., 2008, 693, 1346-1352.
22. Lukevics E., Ignatovich L., Shul'ga T., Belyakov S. Synthesis and crystal structure of 1-(4-fluorophenyl)-  and 1-(4-dimethylamino)phenylgermatranes. // Chem.Heterocycl. Comp. (Engl. Ed.)., 2008, 44, 615-620.
23. Ignatovich L., Muravenko V., Shestakova I.,Domracheva I., Popelis J., Lukevics E.  Synthesis and cytotoxic activity of new 2-[(3-aminopropyl)dimethylsilyl]-5-triethylsilylfurans. //Appl. Organomet. Chem., 2010, 24(3), 158 - 161.
24. Ignatovich L., Romanovs V.,  Shestakova I.,Domracheva I., Popelis J., Lukevics E.  Synthesis and biological activity of new 2-[(3-aminopropyl)dimethylsilyl]-5-trialkylgermylfurans. //Khim. Geterocikl. Soed., 2009, 12, 1792-1799.
25. Lukevics E., Abele E., Ignatovich L.  Biologically Active Silacyclanes. // In:  Advances in Heterocyclic Chemistry, 2010, Vol. 99, 107-141.
26. Soualmi S., Ignatovich L., Jouikov V. Cation radicals of organogermatranes.// Appl. Organomet. Chem. 2010, 24(12), 865-87.
27. Ignatovich L., Romanovs V., Spura J., Popelis J., Domracheva I., Shestakova I. Synthesis and antitumor activity of 3-[(Methyl)bis(5-trialkylsilylfuran-2-yl)silyl]propylamines. //Chem.Heterocycl.Comp. (Engl. Ed.), 2011, 47(12), 1502-1508.
28. Ignatovich L., Muravenko V., Spura J., Popelis J., Domrachova I., Shestakova I. Synthesis, Structure and Cytotoxicity of New 2-[(3-Aminopropyl)dimethylsilyl]-5-furfural Diethylacetals and 2-[(3-Aminopropyl)-dimethylsilyl]-5-phenylfurans. //Appl. Organomet.Chem., 2013, 27(7), 406-411.
29. Ignatovich L., Starkova O., Romanovs V., Sleiksha I., Shestakova I., Popelis J., Lukevics E. Novel Trialkylsilyl(germyl)-substituted Thienyl- and Furylbenzimidazoles and their N-Substituted Derivatives – Synthesis, Structure and Cytotoxic activity. //Comptes Rendus Chimie, 2013, 16(6), 521-627.
30. Ignatovich L., Jouikov V. Organogermatranes and their cation radicals by EPR-spectroelectrochemistry and ab initio calculations. //J. Organomet. Chem. 2014, 751, 546-554. http://dx.doi.org/10.1016/j.jorganchem.2013.08.007
31. Ignatovich L., Romanovs V., Muravenko V., Sleiksha I., Popelis J., Shestakova I. Synthesis and Cytotoxic Activity of 1-{3-[1-(5-Organylsilylfuran-2-yl)silinan-1-yl]propyl}amines and Some Trimethylgermyl Analogues. //Chem.-Eur. J. 2014, 20(40), 12786-12788.
32. Ryabova V., Ignatovich L. Thiophene Substitution Chemistry. /DOI 10.1007/7081_2014_134/. Topics in Heterocyclic Chemistry 2015, Ed. John A Joule, Springer, Switzerland, Vol.39, 43-108.
33. Ignatovich L., Spura J., Muravenko V., Beïakovs S., Popelis J., Shestakova I., Domrachova I, Gulbe A., Rudevica Z., Leonchik A. Synthesis, structure and biological activity of new 6,6-dimethyl-2-oxo-4-{2-[5-organylsilyl(germyl)]furan(thiophen)-2-yl}vinyl-5,6-dihydro-2H-pyran-3-carbonitriles. //Appl. Organomet. Chem. 2015, 29(11), 756-763.

Research Projects:

• L. Ignatovich (Head of Project). Unsaturated Heterocyclic Carbonyl Compounds as Antitumor Agents. Latvian Taiho Foundation (1997 -1999).
• L. Ignatovich (Head of Project). Five Coordinated organogermanium Compounds as Psychotropic and Anticancer Agents. Latvian Taiho Foundation (1999 -2001).
• L. Ignatovich (Head of Project). Diaphorase Activity Regulators: Role in Cancer Chemotherapy. Latvian Taiho Foundation (2001 -2003).
• L. Ignatovich (Head of Project). Metal Complexes of Silyl and Germyl Substituted Oximes and Thiosemicarbazones as Antitumour Agents Inhibiting Topoisomerase II. Latvian Taiho Foundation (2003 -2005).
• L. Ignatovich (Head of Project).Carbofunctional Silylheterocycles.  Latvian Council of Science (2010 - 2012).
• L. Ignatovich (Head of Project).Organic derivatives of hypercoordinate germanium and germyl(silyl)-heterocycles synthesis and investigation of properties (2013-2016).
• L. Ignatovich (WP 2 leader). Strengthening the research and innovation capacities of the Latvian Institute of Organic Synthesis, the leading Baltic regional centre for drug discovery. “InnovaBalt”. Project Coordinator – LIOS director, Professor Ivars Kalvinsh. Project Manager – LIOS, Head of the Laboratory of Pharmaceutical Pharmacology Dr. Maija Dambrova  

Last update 09.02.2016