Ausma KUMEROVA

Dr. Ausma KUMEROVA Senior Researcher Head of Biochemical Laboratory Riga Stradins University Dzirciema iela 16 Riga, LV 1007 LATVIA Phone: + 371 7409143 Fax: + 371 7828155 E-mail: [email protected]

Born: June 6, 1939, Riga, Latvia

Interests:

• Clinical Chemistry
• Medical Biochemistry

Main Research:

    The field of our laboratory investigations are free radicals in health and disease. We study relationship between antioxidative defence (antioxidant enzymes, total antioxidant capacity, level of main bioantioxidants, products of peroxidation etc), overload or deficiency of trace elements (Pb, Zn, Cu, Se), its active proteins (SOD, ceruloplasmin, glutathione enzymes) in patients with various diseases, in persons followed ionizing radiation, pregnant women etc.

Languages: Latvian, Russian, Germany, English

Education:

• University of Latvia (Faculty of Biology), cum laude, 1965
• Dr. biol.(Candidate of Science in former USSR, Ph.D. in Western countries), Moscow 2-nd Medical Institute, Russia, 1983

Experience:

• Engineer and Researcher, Institute of Organic Synthesis, Latvian Academy of Sciences, 1965 -1974

     Medical Academy of Latvia -

• Researcher and Senior Researcher, 1976 - 1993
• Head of Biochemical Laboratory, 1993 -
• Chief on scientific study of students, residents and doctorands.

Professional Activities and Memberships:

• Member, Federation of European Biochemical Societies (FEBS), 1970 -
• Member, Society of Free Radical Research (SFRR), 1996 -

Courses:

• Selected Topics in Biochemistry, Department of Biochemistry, Medical Academy of Latvia ,1993
• PC programme for statistics

 

Recent/Representative Publications:

• A Kumerova, A Silova, L Utno. Effect of Panthetine on postheparin lipolitic activity and lipid peroxidation in myocardium. - Bull. Exp. Biol. Med., 1991 III, N 1, pp. 42-44.
• A Kumerova, L Utno, Z Lipsberga, I Schestere. Myocardial protection by panthothenic acid derivatives in heart model with experimental ischemia and reperfusion. - Bull. Exp. Biol. Med., 1992, vol. 113, pp. 489-492.
• M Veveris, V Klusa, H Cirule, D Meirena, A Kumerova. Cardioprotective properties of Glutapyrone, a novel cyclic peptide - mimiking agent. - European Heart J., 1993, vol.114, Abstr. Supl., p. 408.
• A Kumerova, L Utno, A Schesters, I Schestere. Antiischemic effect and antioxidant activity of derivatives of panthothenic acid in experimental ischemia-reperfusion of the isolated heart. - Proc. Latvian Acad. Sciences, B, 1994, N 1, pp. 73-77.
• A Kumerova, A Schesters, I Schestere. Study of cardioprotective effect of a -Tokopherol and Panthenol using an experimental model of ischemized-reperfuzed isolated heart. - Bull. Exp. Biol. Med., 1994, vol. 117, N 6, pp. 573-575.
• A Kumerova, A Silova, A Lece, V Petukhov. Activity of Glucose-6-phosphate dehydrogenase and Glutathione enzymes in the Red Blood Cells in Patients with hemoblastoses. - Materia Medica Polona, 1995, vol. 27, pp. 7-9.
• A Kumerova, V Petukhov, A Lece, A Silova, A Schesters, Z Lipsberga, V Rijman. The effect of interval normobaric hypoxia on lipid peroxidation, erythrocyte filterability and the blood antioxidant system. - Hypoxia Medical J., 1995, N 3, pp. 15-17.
• A Kumerova, V Petukhov, A Schesters. Method for determination of latent iron deficiency. - Latvian Patent N 10904 (April 20,1996).
• V Petukhov, E Jansons, D Bondare, A Toma, A Schesters, A Kumerova, V Rastrigin, A. Demidova. Role of antioxidant enzymes of RBC in development of anemia in patients with hemoblastoses. - Ter. Archiv, 1992, N 7, pp. 25-29.
• A Kumerova, V Petukhov, A Silova, A Schesters, A Lece. Possibility of the usage of antioxidant enzymes as indicators in characterisation the development of disease in patients with hemoblastoses. - Voprosy Med. Khim., 1996, N 2, pp. 143-147
• A Kumerova, V Petukhov, A Schesters . Determination and informativity of coefficient K for diagnostics deficiency of hemoglobin. - Clin. Lab. Diagnostika, 1996, N 1, pp. 43-44 (in Russian).
• A.Kumerova, A.Lece, A.Silova, A.Skesters.,V.Petukhov, V.Rijman. Interval normobaric hypoxia and antioxidant status in female patients with various diseases. - Croatian Medical J., 1997, vol. 38, N 6, pp. 113-116. 
• V.Petukhov, A.Skesters, A.Kumerova, A.Lece, A.Silova, N.Mironova, M.Krishchune. Erithremia: activity of antioxidant enzymes, connection with iron deficiency. - Ter. Archiv, 1997, N 4, pp. 57-61 (in Russiasn).
• A.Skesters, A.Lece, A.Kumerova. Metabolism of iron and antioxidant defence in blood on healthy volunteers and patients following administration of selenium. - Fundamental and Applied Aspect of Biochemistry, 1998, vol. 2 , Sanct-Petersburg, pp. 432-435 (in Russian).
• A.Skesters, A.Kumerova, I.Skestere. Application of pantothenic acid and its derivatives as cardioprotectors during cardioplegy and reperfusion. - Pantenol and Its Derivatives: Biochemistry, Pharmacology and Medical Application, Grodno, 1998,  pp. 224-230 (in Russian).
• A.Kumerova, A.Lece, A.Skesters, A.Silova, V.Petukhovs. Anaemia and antioxidant defence of the red blood cells. - Materia Medica Polona, 1998, vol. 30, N 1-2 (101), pp. 12-15.
• A.Kumerova, A.Lece, A.Skesters, V.Petukhovs. Anaemia and antioxidant defence of the red blood cells. - Proc. Latv. Acad. Sci., B, 1998, vol. 52, N 3-4, pp. 284-287.
• A.Lece, A.O.Kumerova, A.P.Skesters, J.J.Bikova. Antioxidative defence of blood in early pregnancy. - Bull.Exp.Biol.Med., 1999, N 8, pp. 230-233.
• A.P.Skesters, A.O.Kumerova, A.G. Lece, G.A.Orlikov, J.V.Seleznov, J.J.Pokrotnieks. Disorders in free radical lipid oxidation and rtrace elements amount in the blood of persons worked in an area with elevated ionizing radiation. - Cytologia, 1999, vol. 141, N 9, pp. 804-805.
• A.O.Kumerova, Y.Y.Bikova, A.P.Skesters, AG.Lece, L.N.Gerla, D.A.Uzamecky. The antioxidant state of blood in early periods of pregnancy. - Rossiisky Vestnik Perinatologii i Pediatrii, 1999, vol. 44, N 1, p. 27 (in Russian).

Research Projects:

• A. Kumerova (Head of Project). Study of Antioxidant System in Blood of Patients with Hemoblastoses and Biochemical Mechanism of Antioxidants’ Therapeutic Effect. Latvian Council of Science (1993 - 1996).
• A. Kumerova (Head of Project). The Superoxide Dismutase and Selenium Clinical Testing for Hemoblastoses with Anemia Therapy. TAIHO Latvian Fund (1995 - 1996).
• A. Kumerova (Head of Project). Antioxidative Defence Correction, Significance for Preventive Medicine and Treatment of Patients with Malignant Diseases. Latvian Council of Science (1997 - 1999).
• A. Kumerova (Head of Project). Reactive Oxigen Species and Antioxidants in Experimental and Clinical Study. Latvian Council of Science (2000 - 2002).

Last update 14.03.2000