Aivars KRAUZE
Born: March 16, 1952, Omsk region, Russia
Interests:
- Heterocyclic Chemistry
- Sustainable/Green Chemistry
- Asymmetric synthesis, enzyme catalysed reactions
- Medicinal Chemistry
Research in organic chemistry, especially – partially hydrogenated
nitrogen and sulfur containing heterocycles: dihydro- and tetrahydropyridine-2-thiones,
3-thiazolydenepyridin-2-ones, thieno-, thiazino-, thiazolopyridines; studies of their
chemical, physical-chemical and biological properties. Investigation of Michael reaction,
reactivity of Michael adducts, heterocyclization, multi-component one-pot synthesis,
biomimetic reactions. Search for new pharmaceutically important agents having
antioxidative, hepatoprotective, cardiovascular and neurotropic properties; structure
activity relationship.
Languages: Latvian, Russian, English, German
Education:
Riga Technical University, Faculty of Chemistry, 1975
Dr.chem.(Candidate of Science in former USSR, Ph.D. in Western countries), Latvian
Academy of Sciences, 1985
Thesis: "Synthesis and properties of 3-cyano-3,4-dihydropyridine-2(1H)-thiones"
Experience:
Latvian Institute of Organic Synthesis –
- Researcher, 1975 – 1991
- Senior Researcher, 1991 – 1995
- Researcher, 1995 – 1999
- Principal Scientist, 1999 --
Postdoctoral studies, international experience:
Institute of Drug Research of East-Berlin, Germany (1989, one month)
University of Ghent, Belgium 1991, six months, 1993 six months)
Wageningen Agricultural University, The Netherlands (1997-1998, six months, 2000, two
months)
Institute of Organic Chemistry and Biochemistry, Czech Republic (2002, one month)
Honours and Awards:
- Corresponding Member, Latvian Academy of Sciences, 2006
Award of Academician Solomon Hiller, 2006
Award of Latvian Academy of Sciences for university
students , 1975
Lectures delivered abroad
Berlin, 1989 (in German),
Vilnius, 1995, Prague, 2002 and 2003, Budapest, 2003, Venice, 2004 (in English).
Recent/Representative Publications:
Total number of publications – more than 150, including 10
patents and authors sertificates
- A.Krauze
, J.Popelis, G.Duburs. Synthesis of 4,7(2H)-dihydrothiazolo[3,2-a]pyridines
from 3-carbamoyl-1,4-dihydropyridine-2(3H)-thiones. - Heterocyclic Communications,
1997, vol. 3, N 6, pp. 515-520.
- A.Krauze
, J.Popelis, G.Duburs. Efficient regioselective one-pot synthesis of
partially hydrogenated thiazolo[3,2-a]pyridines. - Tetrahedron, 1998, vol 54, pp.
9161-9168.
- A.Krauze
, S.Germane, O.Eberlins,
I.Sturms, V.Klusa, G.Duburs. Derivatives of
3-cyano-6-phenyl-4-(3’-pyridyl)pyridine-2(1H)-thione and their neurotropic
activity. - Eur.J.Med.Chem., 1999, vol. 34, pp. 301-310.
A.Krauze, R.Vitolina, V.Garaliene, H.-J.Jansch, G.Duburs. Synthesis of 4-substituted
pyridin-2(1H)-ones, pyridine-2(1H)-thiones, related derivatives as analogues of
cardiotonic drug milrinone. - Heterocyclic Communication, 1999, vol. 5, N 6, pp.
569-576.
A.Krauze, G.Duburs. Synthesis, dehydration and oxidation of
3-cyano-4,6-diaryl-5-ethoxycarbonyl-6-hydroxypiperidine-2-thiones. - Heterocyclic
Communications, 2000, vol. 6, N 3, pp. 239-244.
A. Krauze, G.Duburs. Synthesis and
properties of 4,5-trans-4-aryl-3-cyano-6-hydroxy-6-methyl-
5-pyridinio- -1,4,5,6-tetrahydropyridine-2-thiolates. - Heterocyclic Communication,
2000, vol. 6, N 3, pp. 265-270.
Urti Arto, Hyvonen Zanna, Plotniece Aiva, Makarova Natalja, Reine Inese, Tirzitis
Gunars, Vigante Brigita, Shmidlers Andulis, Krauze Aivars, Zhalubovskis Raivis,
Duburs Gunars, Turunen Mikko, Ula-Herttula Seppo, Jaaskelainen Ilpo, Toppinen
Marjo-Riitta. Cationic amphiphilic1,4-dihydropyridines useful for delivery of nucleotide
containing compounds. - Internat.Patent WO 01/62946 A1 (2001). C.A. 135: P 206419h
(2001).
Aivars Krauze, Laura Sile, Gunars
Duburs, Convenient one-pot synthesis of 2-carbamoylmethylthio-3-cyano-
-4,6-diaryl-5-ethoxycarbonyl-1,4-dihydropyridines. – Heterocyclic
Communications, 2001, vol. 7, N 4, pp. 375-380.
Aivars Krauze, Vida Garalene, Rasma
Vitolina, Gunars Duburs. Synthesis of 4,5-dipyridin-2(1H)-ones, pyridine-2(1H)-thiones and
related derivatives as analoges of cardiotonic drug milrinone. - Heterocyclic
Communications, 2001, vol 7, N 5, pp. 427-432.
Aivars Krauze, Andrejs Kemme, Gunars
Duburs. Synthesis and properties of
4,5-trans-2-alylthio-3-cyano-6-hydroxy-6-methyl-5-pyridinio-1,4,5,6-tetrahydropyridine
iodides.- Chem. Heterocycl. Comp.,(Engl.Ed), 2001, vol. 37, N 12, pp 1541-1548.
D.Tirzite, A.Krauze, A.Zubareva, G.Tirzitis, G.Duburs. Synthesis and antiradical
activity of 5-acetyl-2-alkylthio-4-aryl- -6-ethyl-1,4-dihydropyridine-3-carboxylic
nitriles. - Chem. Heterocycl. Comp.(Engl.Ed), 2002, vol. 38, N 7, pp.
795 – 800.
A.Krauze, L.Sile, G.Duburs. Synthesis
of 3,4’- and 4,4’-dipyridyls as cardiotonics, - XXth
European Colloquium on Heterocyclic Chemistry, Aug. 18-21, 2002, Stockholm, Sweden:
Abstr., 2002, E:3, P.131.
A.Krauze, L.Sile, L. Cernova, G.Duburs. Design
of new cardiotonics by making use principles of green chemistry. - International
Symposium Green Chemistry, Uses and Applications of Renewable Raw Materials, May
19-22, 2003, Poitiers, France: Abstr., 2003, 7-D.
L. Baumane, A. Krauze, L. Chernova,
L. Sile, G. Duburs, J. Stradins. Synthesis
and electrochemical oxidation of
4-aryl-3-carbamoylmetylthio-5-ethoxycarbonyl-1,4-dihydropyridine-3-carbonitriles.- Chem.
Heterocycl. Comp.(Engl.Ed), 2003, vol. 39, N 12,
pp 1591-1599.
A.Krauze, L.Sile, L.Cernova, G.Duburs. Design
of biologically active pyridine-2-thiones by making use principles of green chemistry.- Material
Science and Applied Chemistry (Scientific Proceedings of Riga Technical University),
2003, vol. 7, pp. 7-14.
A. Krauze, M.Vilums, L. Sile, S. Belakovs, G.
Duburs. Green one-pot multi-component synthesis of
2,3-dihydro-7H-thiazolo[3,2-a]pyridine-3-carboxamides. –
Int. Conf. On Organic Synthesis (BOS-2004),
June 27-July 1, Riga, Latvija: Abstr., 2004, PO40, P.92
Krauze, L. Sile, M.Vilums, D. Saman, S.
Belakovs, G. Duburs. A new route to
2-(2-aminothien-3-yl)nicotinonitriles. - XXIst European Colloquium on Heterocyclic
Chemistry, Sept. 12-15, 2004, Sopron, Hungary: Abstr., 2004, MP-73.
A.Krauze, L.Cernova, L.Sile, G.Duburs. Green
one-pot multi-component synthesis of 4,7- dihydrothieno [2,3-b] pyridines. - Green
Solvents for Synthesis, Oct. 3-6, 2004, Bruchsal, Germany: Abstr., 2004, P. 133.
A.Krauze, L.Baumane, L.Sile, M.Vilums,
L.Cernova, R.Vitolina, G.Duburs, J.Stradinš. Synthesis, cardiovascular
activity and electrochemical oxidation of
5-ethoxycarbonyl-2-metylthio-1,4-dihydropyridine-3-carbonitriles.- Chem. Heterocycl.
Comp. (Engl.Ed), 2004, vol. 40, N 7, pp 876-887
.
A. Krauze, L.Cernova, L. Sile, M. Vilums, G. Duburs. “Sustainable design of
biologically active 2-carbamoylmethylthio-1,4-dihydropyridines”. – Conf. On
Knowledge-based Materials and Technologies for Sustainable Chemistry, June 1-5 2005,
Tallinn, Estonia: Abstr., 2005, P22, pp 95.
A.Krauze, I. Šturms, J.Popelis, L.Sile, G.Duburs. Synthesis and
properties of methyl 4,6-diaryl-2(3H)-thioxo-1,4-dihydropyridine-3-carboxylates. – Heterocyclic
Communications, 2005, vol. 11, N 1, pp. 37-42.
Aivars Krauze, Rasma Vitolina, Vida Garaliene, Laura Sile, Vija Kluša,
Gunars Duburs. 5-(1-Pyridinio)-4,5-trans-1,4,5,6-tetrahydropyridine-2-thiolates
– new group of potential cardiotonic drugs. - Eur. J. Med. Chem, 2005, vol.
40, N 11, pp. 1163-1167.
A. Krauze, L. Chernova, M. Vilums,
L. Sile, G. Duburs, Green one-pot multicomponent synthesis of
4-aryl-6-carbamoylmethylthio-5-cyano-2-methyl-1,4-dihydropyridine-3-carboxylic acid methyl
esters. Heterocyclic Communications, 2006, vol. 12, N 3/4, 281-286.
A. Krauze, M. Vilums, L. Sile, G. Duburs. Alternative products in one-pot reaction of
benzylidenemalononitrile, N-methyl thiocarbamoylacetamide and bromoacetophenone. -
Chem. Heterocycl. Comp.(Engl.Ed), 2007, vol. 43, N 5, pp. 653-657.
Current Research Projects:
Hobbies:
Basketball, History of Architecture, Gardening
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Last update 21.12.2007
